11. What does upper motor neurone weakness indicate with regard to the localization of a space-occupying lesion? Posted on April 11, 2023 Correct answer: This may indicate a lesion of the pyramidal pathway. Post navigation Previous Post10. How dangerous is the papilloedema caused by raised intracranial pressure? Next Post12. What does a bitemporal hemianopia indicate with regard to the location of a space-occupying lesion?