7. What happens when an empty appendix is obstructed? Posted on May 5, 2023 Correct answer: A mucocele will form, because of continued secretion of mucus from the goblet cells in the mucosal wall. Post navigation Previous Post6. How long do the pathological changes of appendicitis take to develop once obstruction of the appendix has occurred? Next Post8. Which cells in the appendix secrete mucous?